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Randomised crossover trial to assess the tolerability of LHRH analogue administration

Prostate Cancer and Prostatic Diseases volume 6, pages 187–189 (2003)Cite this article

Abstract

Luteinising hormone releasing hormone (LHRH) analogues are routinely used in the treatment of patients with advanced prostate cancer. This randomised crossover trial was conducted to compare patient comfort and tolerability between two commonly used LHRH analogues: goserelin acetate and leuprorelin acetate.

A total of 50 patients were randomised into two groups, each receiving 6-monthly injections of leuprorelin acetate (a liquid presentation) and goserelin acetate (a depot pellet) and crossing over between treatments. Patients completed a simple visual analogue score for the discomfort felt from the injections. An analysis of variance model was used, and the results found that patients do tolerate leuprorelin acetate (0.589) better than goserelin acetate (1.343) (P<0.001, CI=95%).

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References

  1. Pienta KJ . Etiology epidemiology, and prevention of carcinoma of the prostate. In: Walsh PC, Retik AB, Darracott Vaughan E, Wein AJ, (eds). Campbell's Urology, (7th edn.) WB Saunders Company, Philadelphia, pp 2489–2496. (1998)

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Authors and Affiliations

  1. Department of Urology, Royal Gwent Hospital, Newport, UK

    G Williams, S Lindsay & W G Bowsher

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  1. G Williams
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  2. S Lindsay
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  3. W G Bowsher
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Correspondence to W G Bowsher.

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Williams, G., Lindsay, S. & Bowsher, W. Randomised crossover trial to assess the tolerability of LHRH analogue administration. Prostate Cancer Prostatic Dis 6, 187–189 (2003). https://doi.org/10.1038/sj.pcan.4500625

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  • DOI: https://doi.org/10.1038/sj.pcan.4500625

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