In mice fed a diet supplemented with red clover isoflavones the prostatic epithelium displays a significant increase in the production of estrogen receptor β and the adhesion protein E-cadherin but a decrease in transforming growth factor β1. These proteins are estrogenically-induced markers of proliferation, maintenance of histological architecture, preservation of cell phenotype and reduction of the potential for neoplastic and metastatic transformation. This study suggests that red clover isoflavones represent a non-toxic dietary treatment for prostatic hyperplasia and a reduction in the potential for neoplastic transformation.
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Slater, M., Brown, D. & Husband, A. In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor β and E-cadherin expression but decrease transforming growth factor β1. Prostate Cancer Prostatic Dis 5, 16–21 (2002). https://doi.org/10.1038/sj.pcan.4500546
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