Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Apolipoprotein E genotype is not linked to locally recurrent hormone-refractory prostate cancer

Prostate Cancer and Prostatic Diseases volume 3, pages 107–109 (2000)Cite this article

Abstract

Mechanisms of prostate cancer recurrence during androgen deprivation are poorly understood. Recently, the putative role of apolipoprotein E ɛ4 allele in the aetiology of prostate cancer was raised. To investigate the hypothesis that ɛ4 allele of apolipoprotein E gene predisposes to prostate cancer and is involved in the relapse of hormonal therapy response, 38 hormone-refractory locally recurrent carcinoma samples from 38 prostate cancer patients were screened for apolipoprotein E genotype. The frequency distribution of apolipoprotein E genotypes among tumours did not differ significantly from that among controls. The allele frequency of ɛ4 was 19.7% and 19.3% in tumours and controls, respectively. The results suggest that clinical progression of prostate cancer during androgen withdrawal therapy is not associated with apolipoprotein E genotype.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Clinical Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland

    K Haapala & PA Koivisto

  2. Department of Clinical Chemistry, Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland

    T Lehtimäki & E Ilveskoski

  3. Department of Forensic Medicine, The Medical School, University of Tampere, Tampere, Finland

    E Ilveskoski

Authors
  1. K Haapala
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T Lehtimäki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E Ilveskoski
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. PA Koivisto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K Haapala.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haapala, K., Lehtimäki, T., Ilveskoski, E. et al. Apolipoprotein E genotype is not linked to locally recurrent hormone-refractory prostate cancer. Prostate Cancer Prostatic Dis 3, 107–109 (2000). https://doi.org/10.1038/sj.pcan.4500405

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.pcan.4500405

Keywords

This article is cited by

Search

Advanced search

Quick links