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Indifferent chaperones

How do nonspecific enzymes that help to correct RNA folding identify misfolded structures among similar, properly folded RNAs? It seems that careful discrimination has little to do with it.

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Figure 1: Schematic folding landscape of group-I intron RNAs.


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Jankowsky, E. Indifferent chaperones. Nature 449, 999–1000 (2007).

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