Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Micromanagement of metastasis

Although they were discovered only in the early 1990s, many regulatory functions of microRNAs — naturally occurring short RNA sequences — have already been reported. The latest news is that they mediate cancer spread.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: The microRNA-mediated pathway implicated in metastasis.


  1. Steeg, P. S. Nature Med. 12, 895–904 (2006).

    Article  CAS  Google Scholar 

  2. Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Nature 449, 682–688 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Kent, O. A. & Mendell, J. T. Oncogene 25, 6188–6196 (2006).

    Article  CAS  Google Scholar 

  4. Iorio, M. V. et al. Cancer Res. 65, 7065–7070 (2005).

    Article  CAS  Google Scholar 

  5. Yang, J. et al. Cell 117, 927–939 (2004).

    Article  CAS  Google Scholar 

  6. Clark, E. A., Golub, T. R., Lander, E. S. & Hynes, R. O. Nature 406, 532–535 (2000).

    Article  ADS  CAS  Google Scholar 

  7. Hakem, A. et al. Genes Dev. 19, 1974–1979 (2005).

    Article  CAS  Google Scholar 

  8. Dews, M. et al. Nature Genet. 38, 1060–1065 (2006).

    Article  CAS  Google Scholar 

  9. Dalmay, T. & Edwards, D. R. Oncogene 25, 6170–6175 (2006).

    Article  CAS  Google Scholar 

  10. Hammond, S. M. Trends Mol. Med. 12, 99–101 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Steeg, P. Micromanagement of metastasis. Nature 449, 671–673 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing