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Micromanagement of metastasis

Although they were discovered only in the early 1990s, many regulatory functions of microRNAs — naturally occurring short RNA sequences — have already been reported. The latest news is that they mediate cancer spread.

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Figure 1: The microRNA-mediated pathway implicated in metastasis.


  1. Steeg, P. S. Nature Med. 12, 895–904 (2006).

    CAS  Article  Google Scholar 

  2. Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Nature 449, 682–688 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Kent, O. A. & Mendell, J. T. Oncogene 25, 6188–6196 (2006).

    CAS  Article  Google Scholar 

  4. Iorio, M. V. et al. Cancer Res. 65, 7065–7070 (2005).

    CAS  Article  Google Scholar 

  5. Yang, J. et al. Cell 117, 927–939 (2004).

    CAS  Article  Google Scholar 

  6. Clark, E. A., Golub, T. R., Lander, E. S. & Hynes, R. O. Nature 406, 532–535 (2000).

    ADS  CAS  Article  Google Scholar 

  7. Hakem, A. et al. Genes Dev. 19, 1974–1979 (2005).

    CAS  Article  Google Scholar 

  8. Dews, M. et al. Nature Genet. 38, 1060–1065 (2006).

    CAS  Article  Google Scholar 

  9. Dalmay, T. & Edwards, D. R. Oncogene 25, 6170–6175 (2006).

    CAS  Article  Google Scholar 

  10. Hammond, S. M. Trends Mol. Med. 12, 99–101 (2006).

    CAS  Article  Google Scholar 

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Steeg, P. Micromanagement of metastasis. Nature 449, 671–673 (2007).

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