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Chemical biology

More charges against aggregation

Protein aggregation causes problems for biotechnology and leads to many fatal human diseases. But a grasp of the physical principles involved enables 'superproteins' to be designed that have exceptional solubilities.

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Figure 1: An exploration chart of protein amino-acid sequences.


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Vendruscolo, M., Dobson, C. More charges against aggregation. Nature 449, 555 (2007).

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