Local anaesthetics stop pain, but block all other sensations too. In rats, one molecular delivery vehicle makes an unusual local anaesthetic specific for pain — provided a little spice is added to the mix first.
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McCleskey, E. A local route to pain relief. Nature 449, 545–546 (2007). https://doi.org/10.1038/449545a
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DOI: https://doi.org/10.1038/449545a
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Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314
Communications Biology (2018)