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From stem to stern

Immortality is the stuff of myth and legend, but lifespan extension is the subject of serious scientific inquiry. Exploring the causes and effects of ageing in stem cells should aid this quest.

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Figure 1: Interplay between factors and networks influencing ageing.


  1. Rando, T. A. Nature 441, 1080–1086 (2006).

    CAS  Article  ADS  Google Scholar 

  2. Nijnik, A. et al. Nature 447, 686–690 (2007).

    CAS  Article  ADS  Google Scholar 

  3. Rossi, D. J. et al. Nature 447, 725–729 (2007).

    CAS  Article  ADS  Google Scholar 

  4. Chambers, S. M. et al. PLoS Biol. 5, e201 (2007).

    Article  Google Scholar 

  5. Brack, A. S. et al. Science 317, 807–810 (2007).

    CAS  Article  ADS  Google Scholar 

  6. Finkel, T. & Holbrook, N. J. Nature 408, 239–247 (2000).

    CAS  Article  ADS  Google Scholar 

  7. Lombard, D. B. et al. Cell 120, 497–512 (2005).

    CAS  Article  Google Scholar 

  8. Shizuru, J. A., Negrin, R. S. & Weissman, I. L. Annu. Rev. Med. 56, 509–538 (2005).

    CAS  Article  Google Scholar 

  9. Dumble, M. et al. Blood 109, 1736–1742 (2007).

    CAS  Article  Google Scholar 

  10. Janzen, V. et al. Nature 443, 421–426 (2006).

    CAS  Article  ADS  Google Scholar 

  11. Tothova, Z. et al. Cell 128, 325–339 (2007).

    CAS  Article  Google Scholar 

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Brunet, A., Rando, T. From stem to stern. Nature 449, 288–291 (2007).

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