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New uses for old drugs

It takes too long and costs too much to bring new drugs to market. So let's beef up efforts to screen existing drugs for new uses, argue Curtis R. Chong and David J. Sullivan Jr.

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  1. DiMasi, J. A., Hansen, R. W. & Grabowski, H. G. J. Health Econ. 22, 151–185 (2003).

    Article  Google Scholar 

  2. Cohen, F. J. Nature Rev. Drug Discov. 4, 78–84 (2005).

    Article  CAS  Google Scholar 

  3. Ashburn, T. T. & Thor, K. B. Nature Rev. Drug Discov. 3, 673–683 (2004).

    Article  CAS  Google Scholar 

  4. Rothstein, J. D. et al. Nature 433, 73–77 (2005).

    Article  ADS  CAS  Google Scholar 

  5. Moran, M. PLoS Med. 2, e302 (2005).

    Article  Google Scholar 

  6. Sundar, S. et al. N. Engl. J. Med. 347, 1739–1746 (2002).

    Article  CAS  Google Scholar 

  7. Chong, C. R. et al. Nature Chem. Biol. 2, 415–416 (2006).

    Article  CAS  Google Scholar 

  8. Lipinski, C. A. et al. Adv. Drug Deliv. Rev. 46, 3–26 (2001).

    Article  CAS  Google Scholar 

  9. Sussman, G. L. et al. J. Allergy Clin. Immunol. 104, 100–106 (1999).

    Article  CAS  Google Scholar 

  10. Weber, W. W. Mol. Diagn. 4, 299–307 (1999).

    Article  CAS  Google Scholar 

  11. Voigt, J. H. et al. J. Chem. Inf. Comput. Sci. 41, 702–712 (2001).

    Article  CAS  Google Scholar 

  12. Wishart, D. S. et al. Nucleic Acids Res. 34, D668–D672 (2006).

    Article  CAS  Google Scholar 

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We thank Walter Pudelko for invaluable help with Supplementary Table 2.

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Chong, C., Sullivan, D. New uses for old drugs. Nature 448, 645–646 (2007).

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