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Genomic biology

The epigenomic era opens

Nature volume 448, pages 548–549 (2007)Cite this article

Readout of information from the genome depends on intricate regulation of how DNA is packaged by proteins. The great endeavour to reveal how this packaging operates pan-genomically is now under way.

A new era is opening for biologists involved in understanding cellular systems. It is exemplified by papers by Mikkelsen et al. (page 553 of this issue)1 and Barski et al. (published in Cell)2 — they describe the kind of unprecedented insights that are emerging from investigations of how a single mammalian genome can be regulated to produce different cell types.

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Figure 1: Genomic architecture, and eras of investigation.

References

  1. Mikkelsen, T. S. et al. Nature 448, 553–560 (2007).

    Article  ADS  CAS  Google Scholar 

  2. Barski, A. et al. Cell 129, 823–837 (2007).

    Article  CAS  Google Scholar 

  3. Watson, J. D. & Crick, F. H. C. Nature 171, 737–738 (1953).

    Article  ADS  CAS  Google Scholar 

  4. Lander, E. S. et al. Nature 409, 860–921 (2001).

    Article  ADS  CAS  Google Scholar 

  5. Venter, J. C. et al. Science 291, 1304–1351 (2001).

    Article  ADS  CAS  Google Scholar 

  6. Li, B., Carey, M. & Workman, J. L. Cell 128, 707–719 (2007).

    Article  CAS  Google Scholar 

  7. Jenuwein, T. & Allis, C. D. Science 293, 1074–1080 (2001).

    Article  CAS  Google Scholar 

  8. Bernstein, B. E., Meissner, A. & Lander, E. S. Cell 128, 669–681 (2007).

    Article  CAS  Google Scholar 

  9. Kapranov, P. et al. Science 316, 1484–1488 (2007).

    Article  ADS  CAS  Google Scholar 

  10. Albiez, H. et al. Chromosome Res. 14, 707–733 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Stephen B. Baylin and Kornel E. Schuebel are at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 North Broadway, Baltimore, Maryland 21231, USA. sbaylin@jhmi.edu,

    Stephen B. Baylin & Kornel E. Schuebel

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  1. Stephen B. Baylin
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  2. Kornel E. Schuebel
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Baylin, S., Schuebel, K. The epigenomic era opens. Nature 448, 548–549 (2007). https://doi.org/10.1038/448548a

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