Mutations that cause portions of two genes to fuse together and form a hybrid gene are frequent in blood-related cancers. New findings implicate one such fusion gene in the most common type of lung cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Parkin, D. M., Bray, F., Ferlay, J. & Pisani P. CA Cancer J. Clin. 55, 74–108 (2005).
Soda, M. et al. Nature 448, 561–566 (2007).
Sawyers, C. Nature 432, 294–297 (2004).
Druker, B. J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).
de Klein, A. et al. Nature 300, 765–767 (1982).
Morris, S. W. et al. Science 263, 1281–1284 (1994).
Sharma, S. V., Bell, D. W., Settleman, J. & Haber D. A. Nature Rev. Cancer 7, 169–181 (2007).
Lynch, T. J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Paez, J. G. et al. Science 304, 1497–1500 (2004).
Pao, W. et al. Proc. Natl Acad. Sci. USA 101, 13306–13311 (2004).
Tomlins, S. A. et al. Science 310, 644–648 (2005).
Tomlins, S. A. et al. Nature 448, 595–599 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyerson, M. Broken genes in solid tumours. Nature 448, 545–546 (2007). https://doi.org/10.1038/448545a
Published:
Issue Date:
DOI: https://doi.org/10.1038/448545a
This article is cited by
-
Advances in understanding cancer genomes through second-generation sequencing
Nature Reviews Genetics (2010)