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Sensing the enemy within

Damaged or foreign DNA stimulates immune responses by inducing the production of interferon proteins. New evidence indicates that this response is mediated by a cytosolic DNA sensor known as DAI.

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Figure 1: Recognition of DNA by DAI.


  1. Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).

    Article  CAS  Google Scholar 

  2. Takaoka, A. et al. Nature 448, 501–505 (2007).

    Article  ADS  CAS  Google Scholar 

  3. Rotem, Z., Cox, R. A. & Isaacs, A. Nature 197, 564–566 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Jensen, K. E., Neal, A. L., Owens, R. E. & Warren, J. Nature 200, 433–434 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Meylan, E., Tschopp, J. & Karin, M. Nature 442, 39–44 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Hochrein, H. et al. Proc. Natl Acad. Sci. USA 101, 11416–11421 (2004).

    Article  ADS  CAS  Google Scholar 

  7. Stetson, D. B. & Medzhitov, R. Immunity 24, 93–103 (2006).

    Article  CAS  Google Scholar 

  8. Ishii, K. J. et al. Nature Immunol. 7, 40–48 (2006).

    Article  CAS  Google Scholar 

  9. Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U. & Rich, R. Nature Struct. Biol. 8, 761–765 (2001).

    Article  CAS  Google Scholar 

  10. Ha, S. C. et al. Biochim. Biophys. Acta 1764, 320–323 (2006).

    Article  CAS  Google Scholar 

  11. Okabe, Y., Kawane, K., Akira, S., Taniguchi, T. & Nagata, S. J. Exp. Med. 202, 1333–1339 (2005).

    Article  CAS  Google Scholar 

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Chi, H., Flavell, R. Sensing the enemy within. Nature 448, 423–424 (2007).

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