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Narcissistic helpers

T helper-17 cells, which are involved in immune responses, arise from a pool of precursor cells. It emerges that their differentiation is partly mediated by the IL-21 protein, which originates from the helper cells themselves.

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Figure 1: Development of the TH17-cell lineage.


  1. Nurieva, R. et al. Nature 448, 480–483 (2007).

    Article  CAS  Google Scholar 

  2. Korn, T. et al. Nature 448, 484–487 (2007).

    Article  CAS  Google Scholar 

  3. Zhou, L. et al. Nature Immunol. doi:10.1038/ni1488 (2007).

  4. Weaver, C. T. et al. Annu. Rev. Immunol. 25, 821–852 (2007).

    Article  CAS  Google Scholar 

  5. Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. Immunity 24, 179–189 (2006).

    Article  CAS  Google Scholar 

  6. Mangan, P. R. et al. Nature 441, 231–234 (2006).

    Article  CAS  Google Scholar 

  7. Bettelli, E. et al. Nature 441, 235–238 (2006).

    Article  CAS  Google Scholar 

  8. Ivanov, I. I. et al. Cell 126, 1121–1133 (2006).

    Article  CAS  Google Scholar 

  9. Murphy, C. A. et al. J. Exp. Med. 198, 1951–1957 (2003).

    Article  CAS  Google Scholar 

  10. Mehta, D. S., Wurster, A. L. & Grusby, M. J. Immunol. Rev. 202, 84–95 (2004).

    Article  CAS  Google Scholar 

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Palmer, M., Weaver, C. Narcissistic helpers. Nature 448, 416–417 (2007).

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