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Cell biology

Caught in the traffic

In mice, deletion of the Rab8 protein disrupts organized molecular distribution to membranes of intestinal epithelial cells. Death by starvation follows, exactly as it does in humans with microvillus inclusion disease.

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Figure 1: The many functions of Rab8.

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Lakkaraju, A., Rodriguez-Boulan, E. Caught in the traffic. Nature 448, 266–267 (2007). https://doi.org/10.1038/448266a

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