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New order for thought disorders

Can we really learn about complex human psychiatric disorders through genetic manipulations in mice? Yes, according to studies of how altering the gene encoding neuregulin 1 affects signalling in the mouse brain.

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Figure 1: Neuregulin's role in synaptic transmission.
Figure 2: An 'inverted-U model' of Nrg1 signalling.


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Role, L., Talmage, D. New order for thought disorders. Nature 448, 263–265 (2007).

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