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Gene transcription

Extending the message

During transcription, RNA polymerase catalyses the addition of nucleotides to the growing RNA chain. High-resolution structural snapshots indicate that the polymerase first identifies its substrate, and then incorporates it.

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Figure 1: Two-step mechanism of RNA chain elongation during transcription.

References

  1. Vassylyev, D. G., Vassylyeva, M. N., Perederina, A., Tahirov, T. H. & Artsimovitch, I. Nature 448, 157–162 (2007).

    ADS  CAS  Article  Google Scholar 

  2. Vassylyev, D. G. et al. Nature 448, 163–168 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Gnatt, A. L., Cramer, P., Fu, J., Bushnell, D. A. & Kornberg, R. D. Science 292, 1876–1882 (2001).

    ADS  CAS  Article  Google Scholar 

  4. Westover, K. D., Bushnell, D. A. & Kornberg, R. D. Cell 119, 481–489 (2004).

    CAS  Article  Google Scholar 

  5. Kettenberger, H., Armache, K.-J. & Cramer, P. Mol. Cell 16, 955–965 (2004).

    CAS  Article  Google Scholar 

  6. Wang, D., Bushnell, D. A., Westover, K. D., Kaplan, C. D. & Kornberg, R. D. Cell 127, 941–954 (2006).

    CAS  Article  Google Scholar 

  7. Korzheva, N. et al. Science 289, 619–625 (2000).

    ADS  CAS  Article  Google Scholar 

  8. Sosunov, V. et al. EMBO J. 22, 2234–2244 (2003).

    CAS  Article  Google Scholar 

  9. Cramer, P., Bushnell, D. A. & Kornberg, R. D. Science 292, 1863–1876 (2001).

    ADS  CAS  Article  Google Scholar 

  10. Steitz, T. A. Nature 391, 231–232 (1998).

    ADS  CAS  Article  Google Scholar 

  11. Yin, Y. W. & Steitz, T. A. Cell 116, 393–404 (2004).

    CAS  Article  Google Scholar 

Download references

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Cramer, P. Extending the message. Nature 448, 142–143 (2007). https://doi.org/10.1038/448142a

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