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Gene transcription

Extending the message

During transcription, RNA polymerase catalyses the addition of nucleotides to the growing RNA chain. High-resolution structural snapshots indicate that the polymerase first identifies its substrate, and then incorporates it.

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Figure 1: Two-step mechanism of RNA chain elongation during transcription.


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Cramer, P. Extending the message. Nature 448, 142–143 (2007).

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