The inability to efficiently deliver small interfering RNAs to target organs hinders their therapeutic application. So a demonstration of siRNA delivery to a notoriously difficult organ — the brain — is very exciting indeed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kim, D. H. & Rossi, J. J. Nature Rev. Genet. 8, 173–184 (2007).
Martin, S. E. & Caplen, N. J. Annu. Rev. Genomics Hum. Genet. doi: 10.1146/annurev.genom.8.080706.092424 (2007).
Kumar, P. et al. Nature 448, 39–43 (2007).
Pardridge, W. M. Adv. Drug Deliv. Rev. 59, 141–152 (2007).
Davidson, B. L. & Boudreau, R. L. Neuron 53, 781–788 (2007).
Xia, H. et al. Nature Med. 10, 816–820 (2004).
Wong, L.-F. et al. Hum. Gene Ther. 17, 1–9 (2006).
Wender, P. A. et al. Proc. Natl Acad. Sci. USA 97, 13003–13008 (2000).
Gotti, C. & Clementi, F. Prog. Neurobiol. 74, 363–396 (2004).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Cantin, E., Rossi, J. Entry granted. Nature 448, 33–34 (2007). https://doi.org/10.1038/448033a
Published:
Issue Date:
DOI: https://doi.org/10.1038/448033a