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Neurophysiology

Stressful pacemaking

In Parkinson's disease, dopamine-secreting neurons die — perhaps because unrelenting calcium entry during spontaneous electrical activity puts them under unusual pressure.

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Figure 1: Electrical pacemaking and calcium currents.

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Bean, B. Stressful pacemaking. Nature 447, 1059–1060 (2007). https://doi.org/10.1038/4471059a

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