Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chemical biology

A degrading solution to pollution

Nature volume 446, pages 499–500 (2007)Cite this article

Environmental pollutants such as dioxins affect human health. It now seems that dioxins exert their effect by forming atypical enzyme complexes that mediate the breakdown of steroid-hormone receptors.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Dioxins and the degradation of the oestrogen receptor (ERα).

References

  1. Schecter, A., Birnbaum, L., Ryan, J. J. & Constable, J. D. Environ. Res. 101, 419–428 (2006).

    Article  CAS  Google Scholar 

  2. Thornton, J. W., McCally, M. & Haoulihan, J. Public Health Rep. 117, 315–323 (2002).

    Article  Google Scholar 

  3. Brosens, J. J. & Parker, M. G. Nature 423, 545–550 (2003).

    Article  Google Scholar 

  4. Petersen, S. L., Krishnan, S. & Hudgens, E. D. Endocrinology 147, S33–S42 (2006).

    Article  CAS  Google Scholar 

  5. Ohtake, F. et al. Nature 446, 562–566 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Ohtake, F. et al. Nature 423, 545–550 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Wormke, M. et al. Mol. Cell. Biol. 23, 1843–1855 (2003).

    Article  CAS  Google Scholar 

  8. Pickart, C. M. & Eddins, M. J. Biochim. Biophys. Acta 1695, 55–72 (2004).

    Article  CAS  Google Scholar 

  9. Jin, J. et al. Mol. Cell 23, 709–721 (2006).

    Article  CAS  Google Scholar 

  10. Angers, S. et al. Nature 443, 590–593 (2006).

    Article  ADS  CAS  Google Scholar 

  11. Higa, L. A. et al. Nature Cell Biol. 8, 1277–1283 (2006).

    Article  CAS  Google Scholar 

  12. He, Y. J. et al. Genes Dev. 20, 2949–2954 (2006).

    Article  CAS  Google Scholar 

  13. Baba, T. et al. Mol. Cell. Biol. 25, 10040–10051 (2005).

    Article  CAS  Google Scholar 

  14. Dharmasiri, N., Dharmasiri, S. & Estelle, M. Nature 435, 441–445 (2005).

    Article  ADS  CAS  Google Scholar 

  15. Tarpey, P. S. et al. Am. J. Hum. Genet. 80, 345–352 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. J. Wade Harper is in the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. wade_harper@hms.harvard.edu,

    J. Wade Harper

Authors
  1. J. Wade Harper
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harper, J. A degrading solution to pollution. Nature 446, 499–500 (2007). https://doi.org/10.1038/446499a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/446499a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing