Inhibition of the insulin-signalling pathway leads to insulin resistance, an early step in the development of type 2 diabetes. A novel family of protein activators seems to act near the pathway's inception.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Biddinger, S. B. & Kahn, C. R. Annu. Rev. Physiol. 68, 123–158 (2006).
Taniguchi, C. M., Emanuelli, B. & Kahn, C. R. Nature Rev. Mol. Cell Biol. 7, 85–96 (2006).
Hafner, M. et al. Nature 444, 941–944 (2006).
Fuss, B., Becker, T., Zinke, I. & Hoch, M. Nature 444, 945–948 (2006).
Jackson, C. L. & Casanova, J. E. Trends Cell Biol. 10, 60–67 (2000).
Cox, R., Mason-Gamer, R. J., Jackson, C. L. & Segev, N. Mol. Biol. Cell 15, 1487–1505 (2004).
Zeeh, J. C. et al. J. Biol. Chem. 281, 11805–11814 (2006).
Mayer, G. et al. Proc. Natl Acad. Sci. USA 98, 4961–4965 (2001).
Cullen, P. J. & Chardin, P. Curr. Biol. 10, R876–R878 (2000).
Czech, M. P. Cell 100, 603–606 (2000).
Li, H. S. et al. BMC Cell Biol. 4, 13 (2003).
About this article
Cite this article
Jackson, C. Kicking off the insulin cascade. Nature 444, 833–834 (2006). https://doi.org/10.1038/444833a
This article is cited by
Cell Biochemistry and Biophysics (2012)
α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt
Journal of Bioenergetics and Biomembranes (2012)