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Diabetes

Kicking off the insulin cascade

Nature volume 444, pages 833–834 (2006)Cite this article

Inhibition of the insulin-signalling pathway leads to insulin resistance, an early step in the development of type 2 diabetes. A novel family of protein activators seems to act near the pathway's inception.

Many of the cellular processes that are vital for human health are regulated by the insulin/insulin-like growth factor signalling pathway, including glucose homeostasis, fat metabolism, cell growth and differentiation, and ageing1,2. Defects in this pathway are central to the development of obesity and related diseases such as diabetes, in cancer and in the process of ageing. In this issue, Hafner et al. (page 941)3 and Fuss et al. (page 945)4 report the exciting discovery of a group of factors involved in the insulin-signalling pathway — the ARNO/cytohesin family of Arf activators.

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Figure 1: The insulin-signalling cascade.

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  1. the Laboratory of Enzymology and Structural Biochemistry, Bat 34, CNRS, 91198 Gif sur Yvette, France

    Catherine Jackson

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  1. Catherine Jackson
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Jackson, C. Kicking off the insulin cascade. Nature 444, 833–834 (2006). https://doi.org/10.1038/444833a

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