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Leukaemia

Niche retreats for stem cells

Nature volume 444, pages 827–828 (2006)Cite this article

Leukaemic cells and normal blood-producing cells relate differently to their surroundings. This concept has now been extended to leukaemic stem cells, suggesting a fresh approach to therapy.

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Figure 1: Putative migration of stem cells between the bloodstream and bone marrow.

References

  1. Jin, L., Hope, K. J., Zhai, Q., Smadja-Joffe, F. & Dick, J. E. Nature Med. 12, 1167–1174 (2006).

    Article  Google Scholar 

  2. Krause, D. S., Lazarides, K., von Andrian, U. H. & Van Etten, R. A. Nature Med. 12, 1175–1180 (2006).

    Article  CAS  Google Scholar 

  3. Lord, B. I., Testa, A. G. & Hendry, J. H. Blood 46, 65–72 (1975).

    CAS  Google Scholar 

  4. Dexter, T. M. et al. J. Cell Physiol. 91, 335–344 (1976).

    Article  Google Scholar 

  5. Nilsson, S. K., Johnston, H. M. & Coverdale, J. A. Blood 97, 2293–2299 (2001).

    Article  CAS  Google Scholar 

  6. Calvi, L. M. et al. Nature 425, 841–846 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C. & Morrison, S. J. Cell 121, 1109–1121 (2005).

    Article  CAS  Google Scholar 

  8. Cancelas, J. A. et al. Nature Med. 11, 886–891 (2005).

    Article  CAS  Google Scholar 

  9. Lapidot, T. et al. Nature 367, 645–648 (1994).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati, 45229, Ohio, USA

    David A. Williams

  2. Hoxworth Blood Center, University of Cincinnati Medical Center, Cincinnati, 45267, Ohio, USA

    Jose A. Cancelas

Authors
  1. David A. Williams
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  2. Jose A. Cancelas
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Williams, D., Cancelas, J. Niche retreats for stem cells. Nature 444, 827–828 (2006). https://doi.org/10.1038/444827a

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