Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Niche retreats for stem cells

Leukaemic cells and normal blood-producing cells relate differently to their surroundings. This concept has now been extended to leukaemic stem cells, suggesting a fresh approach to therapy.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Putative migration of stem cells between the bloodstream and bone marrow.


  1. Jin, L., Hope, K. J., Zhai, Q., Smadja-Joffe, F. & Dick, J. E. Nature Med. 12, 1167–1174 (2006).

    Article  Google Scholar 

  2. Krause, D. S., Lazarides, K., von Andrian, U. H. & Van Etten, R. A. Nature Med. 12, 1175–1180 (2006).

    CAS  Article  Google Scholar 

  3. Lord, B. I., Testa, A. G. & Hendry, J. H. Blood 46, 65–72 (1975).

    CAS  Google Scholar 

  4. Dexter, T. M. et al. J. Cell Physiol. 91, 335–344 (1976).

    Article  Google Scholar 

  5. Nilsson, S. K., Johnston, H. M. & Coverdale, J. A. Blood 97, 2293–2299 (2001).

    CAS  Article  Google Scholar 

  6. Calvi, L. M. et al. Nature 425, 841–846 (2003).

    ADS  CAS  Article  Google Scholar 

  7. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C. & Morrison, S. J. Cell 121, 1109–1121 (2005).

    CAS  Article  Google Scholar 

  8. Cancelas, J. A. et al. Nature Med. 11, 886–891 (2005).

    CAS  Article  Google Scholar 

  9. Lapidot, T. et al. Nature 367, 645–648 (1994).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Williams, D., Cancelas, J. Niche retreats for stem cells. Nature 444, 827–828 (2006).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing