Figure 1: PGC-1α in mitochondrial biogenesis and antioxidant defence1,2,3. | Nature

Figure 1: PGC-1α in mitochondrial biogenesis and antioxidant defence1,2,3.

From: A clean energy programme

Figure 1

Many external stimuli that signal an increase in the need for energy can activate PGC-1α. By acting on members of the nuclear-receptor superfamily — including NRF-1, NRF-2 and ERR-α — PGC-1α can induce mitochondrial biogenesis. The resulting production of reactive oxygen species (ROS; oxidative stress) may feed back through the CREB gene-regulatory factor, leading to further increases in PGC-1α. This oxidant-induced increase in PGC-1α is then necessary to stimulate expression of a host of antioxidant proteins, including forms of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase.

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