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Cancer biology

Second step to retinal tumours

The mutations that cause retinoblastoma are well known, but how they enable the cancer to evade controls on cell division was unclear. Secondary mutations affecting a growth-regulatory pathway have now been identified.

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Figure 1: Role of MDM proteins in retinoblastoma.

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Wallace, V. Second step to retinal tumours. Nature 444, 45–46 (2006). https://doi.org/10.1038/444045a

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