Abstract
We do not consider that our inferences about FLASH function are misleading because they were deduced from functional analyses1. We originally identified the death-effector domain (DED)-binding activity of the DED-recruiting domain (DRD) of FLASH before analysing the structural homology between the DED and DRD domains. Moreover, we deduced the self-association activity of FLASH through its central region from functional analysis of several deletion mutants of mouse FLASH. We note that self-association activity of CED-4-homologous proteins is required for the activation of caspases2.
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References
Imai, Y. et al. Nature 398, 777–785 (1999).
Walker, J. E. et al. EMBO J. 1, 945–951 (1982).
Yang, X., Chang, H. Y. & Baltimore, D. Science 281, 1355–1357 (1998).
Muzio, M. et al. Cell 85, 817–827 (1996).
Irmler, M. et al. Nature 388, 190–195 (1997).
Itoh, N. et al. Cell 66, 233–243 (1991).
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Kimura, T., Imai, Y. & Yonehara, S. Searching for FLASH domains. Nature 401, 662–663 (1999). https://doi.org/10.1038/44320
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DOI: https://doi.org/10.1038/44320
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