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Cancer biology

Can less be more for p53?

The tumour-suppressor protein p53 is often mutated in cancer. But it seems that p53 deficiency is not all bad, and inhibiting this protein might mitigate toxic side effects of chemotherapy and radiotherapy.

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Figure 1: Effects of temporary restoration of p53 protein on radiotoxicity and tumour latency.


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Berns, A. Can less be more for p53?. Nature 443, 153–154 (2006).

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