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Cell biology

A licence for duplication

Genome stability in animal cells requires strict control over the numbers of the organelles called centrosomes. An attractive 'licensing' model now explains how centrosome duplication is restricted to just once per cell cycle.

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Figure 1: Proposed role of the enzyme separase in triggering centriole disengagement.

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Nigg, E. A licence for duplication. Nature 442, 874–875 (2006). https://doi.org/10.1038/442874a

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