What's the best way to make a tube? Roll up a sheet? Hollow out a solid rod? Some innovative movies show how the problem is tackled during the development of blood vessels in embryos.
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Mostov, K., Martin-Belmonte, F. The hole picture. Nature 442, 363–364 (2006). https://doi.org/10.1038/442363a
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DOI: https://doi.org/10.1038/442363a