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Protein folding

Inside the cage

Many newly synthesized bacterial proteins avoid aggregation by folding inside a chaperonin nanocage. Unexpectedly, it turns out that the cage's internal properties can be optimized to accelerate folding.

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Figure 1: The GroEL–GroES nanocage in action.

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Ellis, R. Inside the cage. Nature 442, 360–361 (2006). https://doi.org/10.1038/442360a

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