Rubisco is said to be both the most important enzyme on Earth and surprisingly inefficient. Yet an understanding of the reaction by which it fixes CO2 suggests that evolution has made the best of a bad job.
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Griffiths, H. Designs on Rubisco. Nature 441, 940–941 (2006). https://doi.org/10.1038/441940a
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DOI: https://doi.org/10.1038/441940a
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