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Lessons from Italy

Naturevolume 441pages933934 (2006) | Download Citation

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How malaria affected, and was controlled in, Italy in the past century has important messages for today.

The Conquest of Malaria: Italy, 1900–1962

Yale University Press: 2006. 288 pp. £25, $40 0300108990 | ISBN: 0-300-10899-0

Much has been written about the biology of malaria but little about its social and economic impact. Frank Snowden has drawn on neglected Italian sources to produce a detailed account of the protracted struggle to bring malaria under control in Italy. The Conquest of Malaria is an important contribution to the malaria literature.

Snowden, a historian, uses contemporary accounts to illustrate the devastating social and economic consequences of malaria in Italy 100 years ago. On the eve of the First World War, life expectancy in malaria-endemic areas of Italy was only 22.5 years, less than in the least-developed countries today. Malaria was primarily a disease of the poor and was particularly severe among migrant agricultural workers and Sardinian miners who lived in appalling conditions.

Snowden points out that the detailed statistics available on numbers of cases of malaria and malaria deaths provide only a partial picture of the impact of the infection. It was widely recognized at the time that it had a major adverse effect on the economy, contributed to the impoverishment of southern Italy and was probably a contributor to emigration. Through both its direct and indirect effects, malaria may, at its peak, have caused as many as 100,000 deaths per year in Italy.

Italians faced a malaria epidemic at the end of the Second World War after the German army withdrew. Credit: STUDIO PATELLANI/CORBIS

Malaria thrives during periods of turmoil, so it is not surprising that some of the gains in control of the disease made by the time of the First World War were lost during the period of the conflict. Troops and civilians involved directly in fighting in the Veneto region suffered badly, but malaria also surged elsewhere. Snowden attributes this to the return of infected soldiers to susceptible communities, shortages of antimalarial drugs, breakdown in rural health services and, less plausibly, to the 1918 influenza epidemic. During the Second World War, there was again an increase in cases of malaria for similar reasons, but with an additional, more sinister, explanation. Before retreating, the occupying German army flooded the Pontine Marshes, where malaria had previously been controlled, with salt water to create the brackish conditions that favour the breeding of the mosquito Anopheles labranchiae, the main malaria vector in the area. This attempt at biological warfare was successful, resulting in an epidemic of malaria in 1944–46.

The description of the ways in which malaria control in Italy evolved over time provides many important messages for today. At the beginning of the twentieth century, quinine was seen as the main control tool. Its widespread use was highly successful in reducing malaria mortality but less efficacious in reducing the number of cases. This is not surprising as quinine does not prevent relapses of the malaria parasite Plasmodium vivax or kill gametocytes. There was resistance to its use in some areas because of suspicions over the intentions of employers and the government who provided it free. Provision of rural dispensaries, which provided general care as well as malaria treatment, and rural schools helped to overcome these concerns.

After the First World War, vector control started to receive more attention and became a key component of an integrated malaria control programme in the Pontine Marshes that was undertaken by the fascist government. Snowden outlines the political motivation for this successful programme, which allowed 60,000 people to be settled in an area that had previously been largely uninhabitable. After the Second World War, the insecticide DDT became the primary control tool, and its use led to the elimination of local malaria transmission in Italy in 1962. However, this success was built on an enormous amount of background knowledge and experience in malaria control gained during the previous 60 years.

Could this excellent book have been improved in any way? Snowden uses specific events to illustrate general principles but it is sometimes difficult to know how these relate to the overall picture prevailing at that time, and a figure or two summarizing the chronology of events would have been useful. Some more maps would also have helped, for example to show regional differences in incidence rates. Snowden gives a good account of the biological aspects of the story and I found only a few, minor technical points with which I disagree. However, I think he is unfair to the World Health Organization (WHO) in implying an overreliance on the use of insecticide-treated bednets in current malaria control programmes; the WHO also advocates early diagnosis, treatment with effective combination therapy and chemoprevention in pregnancy.

What lessons can be gained from the Italian experience that are relevant to malaria control today? There are many, but the main one, I think, is that malaria can be controlled successfully, even in the most extreme situations. What's needed is an integrated approach —rather than reliance on a single tool — based on sound epidemiological knowledge, supported by an effective rural healthcare and educational programmes, and with a high level of political and financial support. These are demanding requirements, but the Italian story described in this important book shows what will be needed if malaria is to be controlled effectively in Africa today.

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  1. London School of Hygiene and Tropical Medicine, London, WC1B 3DP, UK

    • Brian Greenwood

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https://doi.org/10.1038/441933a

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