Amide bonds underpin protein stability, but distortion from their preferred geometry makes them reactive. An archetypal twisted amide has at last been made, and its chemistry will be revelatory.
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Wasserman, H. Synthesis with a twist. Nature 441, 699–700 (2006). https://doi.org/10.1038/441699a
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DOI: https://doi.org/10.1038/441699a
