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Down's syndrome

Critical genes in a critical region

The NFAT transcription factors activate the expression of many genes involved in the immune response and the development of a variety of tissues. They have now been implicated in Down's syndrome.

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Figure 1: NFAT signalling and Down's syndrome.

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Epstein, C. Critical genes in a critical region. Nature 441, 582–583 (2006). https://doi.org/10.1038/441582a

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