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Adaptable innate killers

Natural killer cells are versatile white blood cells that act in the innate immune system. Quite how adaptable they can be in the absence of other, more specialized, immune cells comes as a surprise.

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Figure 1: Measuring contact sensitivity.


  1. Saary, J. et al. J. Am. Acad. Dermatol. 53, 845 (2005).

    Article  PubMed  Google Scholar 

  2. Askenase, P. W. Clin. Exp. Immunol. 125, 345–350 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. O'Leary, J. G., Goodarzi, M., Drayton, D. L. & von Adrian, U. H. Nature Immunol. 7, 507–516 (2006).

    Article  CAS  Google Scholar 

  4. George, T. et al. Immunol. Rev. 155, 29–40 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. Ruggeri, L. et al. Science 295, 2097–2100 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Arase, H., Mocarski, E. S., Campbell, A. E., Hill, A. B. & Lanier, L. L. Science 296, 1323–1326 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Pende, D. et al. Blood 105, 2066–2073 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Makrigiannis, A. P., Patel, D., Goulet, M. L., Dewar, K. & Anderson, S. K. Genes Immun. 6, 71–83 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Parham, P. Nature Rev. Immunol. 5, 201–214 (2005).

    Article  CAS  Google Scholar 

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Parham, P. Adaptable innate killers. Nature 441, 415–416 (2006).

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