The conventional optical limitations of fluorescence microscopy have been defied, to achieve nanoscale resolution of individual vesicle organelles at the junctions of neuronal cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Klar, T. A. & Hell, S. W. Opt. Lett. 24, 954–956 (1999).
Klar, T. A., Jakobs, S., Dyba, M., Egner, A. & Hell, S. W. Proc. Natl Acad. Sci. USA 97, 8206–8210 (2000).
Hofmann, M., Eggeling, C., Jakobs, S. & Hell, S. W. Proc. Natl Acad. Sci. USA 102, 17565–17569 (2005).
Willig, K. I., Rizzoli, S. O., Westphal, V., Jahn, R. & Hell, S. W. Nature 440, 935–939 (2006).
Pohl, D. W., Denk, W. & Lanz, M. Appl. Phys. Lett. 44, 651–653 (1984).
Harootunian, A. et al. Appl. Phys. Lett. 49, 674–676 (1986).
Smith, D. R. et al. Science 305, 788–792 (2004).
Ramakrishna, S. A. Rep. Prog. Phys. 68, 449–521 (2005).
Egner, A. & Hell, S. W. Trends Cell Biol. 15, 207–215 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Simpson, G. The diffraction barrier broken. Nature 440, 879–880 (2006). https://doi.org/10.1038/440879a
Published:
Issue Date:
DOI: https://doi.org/10.1038/440879a
This article is cited by
-
Near-field focusing and magnification through self-assembled nanoscale spherical lenses
Nature (2009)
-
Nanoscale neuroimaging
Nature Reviews Neuroscience (2006)