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Ageing

Chromatin unbound

Nature volume 440, pages 874–875 (2006)Cite this article

Sir2 proteins slow ageing in yeast by locking chromatin — the DNA and proteins in chromosomes — into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.

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Figure 1: Balancing act.

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Authors and Affiliations

  1. the Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, 94945, California, USA

    Jan Vijg

  2. the Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, 78245, Texas, USA

    Yousin Suh

Authors
  1. Jan Vijg
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  2. Yousin Suh
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Vijg, J., Suh, Y. Chromatin unbound. Nature 440, 874–875 (2006). https://doi.org/10.1038/440874a

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