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Chromatin unbound

Sir2 proteins slow ageing in yeast by locking chromatin — the DNA and proteins in chromosomes — into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.

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Figure 1: Balancing act.


  1. Mostoslavsky, R. et al. Cell 124, 315–329 (2006).

    CAS  Article  Google Scholar 

  2. Henshaw, P. S., Riley, E. F. & Stapleton, G. E. Radiology 49, 349–364 (1947).

    CAS  Article  Google Scholar 

  3. Szilard, L. Proc. Natl Acad. Sci. USA 45, 30–45 (1959).

    ADS  CAS  Article  Google Scholar 

  4. Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Science 299, 1355–1359 (2003).

    CAS  Article  Google Scholar 

  5. Vijg, J. & Suh, Y. Annu. Rev. Med. 56, 193–212 (2005).

    CAS  Article  Google Scholar 

  6. Motta, M. C. et al. Cell 116, 551–563 (2004).

    CAS  Article  Google Scholar 

  7. Cheng, H. L. et al. Proc. Natl Acad. Sci. USA 100, 10794–10799 (2003).

    ADS  CAS  Article  Google Scholar 

  8. Taub, D. D. & Longo, D. L. Immunol. Rev. 205, 72–93 (2005).

    CAS  Article  Google Scholar 

  9. Bartke, A. Endocrinology 146, 3718–3723 (2005).

    CAS  Article  Google Scholar 

  10. Wijnhoven, S. W. et al. DNA Repair (Amst.) 4, 1314–1324 (2005).

    CAS  Article  Google Scholar 

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Vijg, J., Suh, Y. Chromatin unbound. Nature 440, 874–875 (2006).

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