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Chromatin unbound

Sir2 proteins slow ageing in yeast by locking chromatin — the DNA and proteins in chromosomes — into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.

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Figure 1: Balancing act.


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Vijg, J., Suh, Y. Chromatin unbound. Nature 440, 874–875 (2006).

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