Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Rewinding the memory record

How does the brain store sequences of experience? Clues come from brain recordings of rats running along a track. The animals' memories seem to be consolidated in an unexpected way as they rest between runs.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Reverse replay.


  1. Stickgold, R. Nature 437, 1272–1278 (2005).

    ADS  CAS  Article  Google Scholar 

  2. Foster, D. J. & Wilson, M. A. Nature 440, 680–683 (2006).

    ADS  CAS  Article  Google Scholar 

  3. Squire, L. R., Stark, C. E. & Clark, R. E. Annu. Rev. Neurosci. 27, 279–306 (2004).

    CAS  Article  Google Scholar 

  4. Wilson, M. A. & McNaughton, B. L. Science 265, 676–679 (1994).

    ADS  CAS  Article  Google Scholar 

  5. Lee, A. K. & Wilson, M. A. Neuron 36, 1183–1194 (2002).

    CAS  Article  Google Scholar 

  6. Buzsaki, G., Leung, L. W. & Vanderwolf, C. H. Brain Res. 287, 139–171 (1983).

    CAS  Article  Google Scholar 

  7. Klausberger, T. et al. Nature 421, 844–848 (2003).

    ADS  CAS  Article  Google Scholar 

  8. Buzsaki, G. Neuroscience 31, 551–570 (1989).

    CAS  Article  Google Scholar 

  9. O'Neill, J., Senior, T. & Csicsvari, J. Neuron 49, 143–155 (2006).

    CAS  Article  Google Scholar 

  10. O'Keefe, J. & Dostrovsky, J. Brain Res. 34, 171–175 (1971).

    CAS  Article  Google Scholar 

  11. Skinner, B. F. The Behavior of Organisms (Appleton-Century-Crofts, New York, 1938).

    Google Scholar 

  12. Hull, C. L. A Behavior System (Wiley, New York, 1952).

    Google Scholar 

  13. Berridge, K. C. & Robinson, T. E. Brain Res. Rev. 28, 309–369 (1998).

    CAS  Article  Google Scholar 

  14. Montague, P. R., Hyman, S. E. & Cohen, J. D. Nature 431, 760–767 (2004).

    ADS  CAS  Article  Google Scholar 

  15. Schultz, W. Annu. Rev. Psychol. 57, 87–115 (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Colgin, L., Moser, E. Rewinding the memory record. Nature 440, 615–616 (2006).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing