Figure 1 | Cell Death & Differentiation

Figure 1

From: Apoptosome: a platform for the activation of initiator caspases

Figure 1

Apoptotic caspases discussed in the review. Six initiator caspases and four effector caspases in three model species are drawn to scale. The position of the first intrachain cleavage (between the large and small subunits) is highlighted by a large arrow whereas additional cleavages are represented by medium and small arrows. The prodomains in initiator caspases invariably contain homotypic interaction motifs, such as the CARD and the DED.33 The four surface loops, labeled L1 through L4, form the active site of a caspase.7 The catalytic cysteine residue is shown as a red line at the beginning of loop L2. The p20 and p10 subunits together form a caspase monomer

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