Figure 4 | Cell Death & Differentiation

Figure 4

From: Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent

Figure 4

ETB-R-mediated proliferation of SMC in segments of the rabbit jugular vein. The segments were perfused for 6 h at 0 or 20 mm Hg, followed by a 36 h incubation period under static conditions. BQ788 and BQ123 (1 μmol/L each) were administered 20 min before termination of perfusion and throughout the incubation period (n=6–7). Immunohistochemistry for the cell cycle-specific antigen PCNA was performed as described in the Materials and Methods section. The number of PCNA-positive nuclei is expressed relative (%) to the total number of nuclei present in the cross section analyzed. Only nuclei from the intima and media were counted (*P<0.05 versus non-pressurised controls, #P<0.05 versus pressurised controls)

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