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Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation

Cell Death & Differentiation volume 5, pages 720–728 (1998)Cite this article

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

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Affiliations

  1. Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, 00161, Italy

    Carla Fiorentini & Gianfranco Donelli

  2. INSERM U452 Faculté de Médecine, avenue de Valombrose, Nice, Cedex 2, 06107, France

    Michel Gauthier & Patrice Boquet

Authors
  1. Carla Fiorentini
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  2. Michel Gauthier
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  3. Gianfranco Donelli
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  4. Patrice Boquet
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Corresponding author

Correspondence to Carla Fiorentini.

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Edited by R.A. Knight

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Cite this article

Fiorentini, C., Gauthier, M., Donelli, G. et al. Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation. Cell Death Differ 5, 720–728 (1998). https://doi.org/10.1038/sj.cdd.4400412

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  • DOI: https://doi.org/10.1038/sj.cdd.4400412

Keywords

  • Rho
  • C3
  • CNF1
  • cell regulation

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