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Cell biology

A break in the chain?

How chains of proteins link transmembrane cell–cell adhesion molecules to the cell's inner scaffold was standard textbook material. But recent research challenges the accepted model, opening a new chapter in the field.

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Figure 1: The conventional model for how a cadherin links to actin filaments.
Figure 2: The states of α-catenin.

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Burridge, K. A break in the chain?. Nature 440, 38–39 (2006). https://doi.org/10.1038/440038b

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