Cancer cell sensitization to Fas-mediated apoptosis by sodium butyrate

Abstract

Cancer cells often resist Fas-mediated apoptosis even when the Fas receptor is expressed at the cell surface. We show here that human and rat colon cancer cells undergo massive apoptosis when they are exposed to soluble Fas ligand in the presence of sodium butyrate, an agent that induces by itself only a low rate of apoptosis. Sodium butyrate potentiates Fas-dependent apoptosis in seven out of eight colon cancer cell lines. Sodium butyrate does not increase Fas receptor cell surface expression and does not modify cell levels of Bcl-2, Bcl-xL, Bcl-xS and Bax. Sodium butyrate also induces tumor cell sensitization to the apoptotic effect of the combination of TNF-α and IFN-γ, but it does not modify the level of the FADD/Mort1 adaptator molecule, at the connection between Fas- and TNF-dependent apoptosis pathways. Because the clinical toxicity of butyrate is low, its ability to enhance Fas-signal delivery in cancer cells could be of therapeutic interest.

Author information

Affiliations

Authors

Corresponding author

Correspondence to François Martin.

Additional information

Edited by M. Piacentini

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bonnotte, B., Favre, N., Reveneau, S. et al. Cancer cell sensitization to Fas-mediated apoptosis by sodium butyrate. Cell Death Differ 5, 480–487 (1998). https://doi.org/10.1038/sj.cdd.4400371

Download citation

Keywords

  • apoptosis
  • colorectal cancer
  • Fas
  • sodium butyrate

Further reading

Search

Quick links