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Cell biology

Ageing nucleus gets out of shape

Nature volume 440, pages 3234 (02 March 2006) | Download Citation

Subjects

In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.

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Author information

Affiliations

  1. Hannes Lans and Jan H. J. Hoeijmakers are at the MGC-CBG Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000DR, Rotterdam, The Netherlands. J.Hoeijmakers@erasmusmc.nl

    • Hannes Lans
    •  & Jan H. J. Hoeijmakers

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DOI

https://doi.org/10.1038/440032a

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