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Cell biology

Ageing nucleus gets out of shape

Nature volume 440, pages 32–34 (2006)Cite this article

In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.

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Figure 1: Model linking normal and premature ageing with nuclear integrity and genome stability.

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Authors and Affiliations

  1. the MGC-CBG Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, Rotterdam, 3000DR, The Netherlands

    Hannes Lans & Jan H. J. Hoeijmakers

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  1. Hannes Lans
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  2. Jan H. J. Hoeijmakers
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Lans, H., Hoeijmakers, J. Ageing nucleus gets out of shape. Nature 440, 32–34 (2006). https://doi.org/10.1038/440032a

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