In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.
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Lans, H., Hoeijmakers, J. Ageing nucleus gets out of shape. Nature 440, 32–34 (2006). https://doi.org/10.1038/440032a
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DOI: https://doi.org/10.1038/440032a
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