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Parasitology

Switching like for like

To remain hidden from its host's immune system, the malaria parasite must vary the proteins on the surface of the infected cell. The genes encoding these proteins are very similar, so how does the parasite express just one at a time?

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Figure 1: A red blood cell infected with Plasmodium falciparum.
Figure 2: A model for the regulation of var genes in the Plasmodium nucleus.

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Borst, P., Genest, PA. Switching like for like. Nature 439, 926–927 (2006). https://doi.org/10.1038/439926b

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