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Exhausted T cells perk up

During persistent infections, the immune cells responsible for killing infected cells and maintaining inflammation gradually stop functioning, allowing the pathogen to thrive. But can this process be reversed?

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Figure 1: Reviving exhausted T cells.


  1. Barber, D. L. et al. Nature 439, 682–687 (2006).

    Article  ADS  CAS  Google Scholar 

  2. Chemnitz, J. M. et al. J. Immunol. 173, 945–954 (2004).

    Article  CAS  Google Scholar 

  3. Blank, C., Gajewski, T. F. & Mackensen, A. Cancer Immunol. Immunother. 54, 307–314 (2005).

    Article  CAS  Google Scholar 

  4. Nishimura, H. et al. Immunity 11, 141–151 (1999).

    Article  CAS  Google Scholar 

  5. Guleria, I. et al. J. Exp. Med. 202, 231–237 (2005).

    Article  CAS  Google Scholar 

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Williams, M., Bevan, M. Exhausted T cells perk up. Nature 439, 669–670 (2006).

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