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DNA repair

Tails of histones lost

A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.

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Figure 1: Chromatin remodelling around double-stranded DNA breaks.


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Nussenzweig, A., Paull, T. Tails of histones lost. Nature 439, 406–407 (2006).

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